Vitamin D May Be Tied to Heart Disease Via Genes

(HealthDay News) -- New research points to the possibility of a genetic link between vitamin D and heart disease.

People with high blood pressure who had a gene variant that reduces vitamin D activation in the body were found to be twice as likely as those without the variant to have congestive heart failure, the study found.

The finding may lead to a way to identify people at increased risk for heart disease, according to Robert U. Simpson, an assistant professor of pharmacology at the University of Michigan Medical School and his research colleagues.

They analyzed the genetic profiles of 617 people. One-third had hypertension, one-third had hypertension and congestive heart failure, and the remaining third served as healthy controls.

The researchers found that a variant in the CYP27B1 gene was associated with congestive heart failure in people with hypertension. The study is in the November issue of Pharmacogenomics.

Previous research showed that mutations that inactivate the gene reduce the conversion of vitamin D into an active hormone.

"This study is the first indication of a genetic link between vitamin D action and heart disease," Simpson said in a news release from the University of Michigan.

"If subsequent studies confirm this finding and demonstrate a mechanism, this means that, in the future, we may be able to screen earlier for those most vulnerable and slow the progress of the disease," he added.

More information
The American Heart Association has more about congestive heart failure.


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Source: Yahoo News

Vitamin D May Be Tied to Heart Disease Via Genes

Study finds hospitals speeding heart attack care

By LAURAN NEERGAARD, AP Medical Writer

WASHINGTON – Hospitals are giving faster care to lots more heart attack patients, a speed-up sure to be saving lives.

More than three-quarters of people suffering major heart attacks are getting their blocked arteries reopened within 90 minutes of arriving in the emergency room, says a Yale University study of 831 hospitals that participated in a major campaign to accelerate that care.

In 2005, half of patients were getting treated that fast, says Wednesday's study in the Journal of the American College of Cardiology. Cardiac guidelines have long warned that delaying even half an hour longer increases the risk of death.

So the following year, the cardiologist group began an ambitious project to reduce what doctors call "door to balloon time," the time from hospital arrival to getting an angioplasty or similar procedure. Hundreds of hospitals — about 70 percent of those able to perform emergency angioplasties — signed up to share speedy strategies.

It worked, the study found: By spring of 2008, 76 percent of patients who qualified for that kind of care received it in time. More recent data shows continued improvement. Nearly 82 percent of eligible patients had a 90-minute or less door-to-balloon time in those hospitals by last summer.

Hospitals not participating in the campaign didn't improve door-to-balloon times as quickly, the study found.

Study co-author Dr. Harlan Krumholz, a Yale cardiologist, said alerting slower hospitals to the problem allowed them to copy faster competitors. "They all said, 'Wow, we thought we were fast,'" Krumholz recalled.

The changes that helped most were simple steps that cut a few minutes here and few there. One such step was letting the emergency room activate the catheter lab upon the patient's arrival, or even after a call from the ambulance on its way, instead of waiting for a cardiologist to confirm the diagnosis before getting ready for angioplasty. Some hospitals assigned cardiac catheter teams to be on duty 24 hours a day. Others required that on-call doctors arrive within minutes of a page from the ER.

"Nobody got paid an extra dollar for it," Krumholz said of the campaign. "Nobody was being penalized if they didn't do it. This was people saying it's the right thing to do for patients."

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Source: Yahoo News

Study finds hospitals speeding heart attack care